NABOTA 150 Units (Botulinum Toxin Type A)
150 U X 1 vial
Description
NABOTA is Daewoong’s botulinum toxin type A — a purified 900 kDa neurotoxin complex produced through Daewoong’s own patented purification process (KR Patent 10-1339349, registered 2013) for high purity and low impurity. It is supplied as a lyophilized powder, reconstituted with sterile saline before injection. The product is exported to roughly 90 countries, including the United States (marketed there as Jeuveau) and 28 European countries. Ingredients • Active: Clostridium botulinum toxin type A (purified 900 kDa neurotoxin complex), 150 units per vial. • Excipients (typical NABOTA formulation): Human Serum Albumin and Sodium Chloride.
Indication
Temporary improvement of moderate-to-severe glabellar lines (frown lines between the eyebrows) in adults. NABOTA is also used therapeutically (e.g. post-stroke upper limb spasticity). Confirm the exact approved indications for each destination market against the local registration.
Packaging
150 U X 1 vial
Protocol
Reconstitution: 1. Draw up nonpreserved sterile 0.9% sodium chloride (the recommended diluent) per the dilution table. 2. Insert the needle and slowly inject the saline into the vacuum vial. 3. Inject slowly, avoiding bubbles. 4. Gently mix until the solution is completely clear with no visible particles. 5. Record the date and time of reconstitution; administer within 24 hours. 6. Store the reconstituted product refrigerated (2–8°C). Dilution table (official figures — for 50 U / 100 U / 200 U): |Diluent added (50 U)|(100 U)|(200 U)|Resulting dose (U/0.1 mL)| |--------------------|-------|-------|-------------------------| |0.5 mL |1.0 mL |2.0 mL |10.0 U | |1.0 mL |2.0 mL |4.0 mL |5.0 U | |1.25 mL |2.5 mL |5.0 mL |4.0 U | |2.0 mL |4.0 mL |8.0 mL |2.5 U | |4.0 mL |8.0 mL |16.0 mL|1.25 U | Note: 150 U is not in Daewoong’s published table — scale the diluent proportionally to the desired concentration (e.g. 3.75 mL for 4.0 U/0.1 mL) and follow the official package insert. Glabella injection: Using a sterile 30-gauge needle, inject 0.1 mL into each of 5 sites — 2 in each corrugator muscle and 1 in the procerus muscle — for a total of 20 units. Stability after reconstitution (per Daewoong data): potency maintained when stored frozen up to 4 months, at room temperature up to 5 weeks, and through up to 4 freeze/thaw cycles. Korean registration requires use within 24 hours of dilution, kept refrigerated (2–8°C).
